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IGF1R
This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014]
Date: 11/13/2024
Organized By: Creative Biogene
Contact: contact@creative-biogene.com
Web: https://www.creative-biogene.com/genesearch/IGF1R.html
Email: contact@creative-biogene.com
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