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Understanding Asthma – Pathophysiology And Treatment

Dr. Indrajeet Tyagi and Dr. Iranna Hirapur
11/13/2025

Understanding Asthma – Pathophysiology And Treatment
by Dr. Indrajeet Tyagi and Dr. Iranna Hirapur

Asthma is one of the most common chronic respiratory diseases affecting both children and adults across the world. It is characterized by episodes of breathlessness, coughing, wheezing, and chest tightness, which can range from mild to life threatening. Although asthma cannot be cured, it can be effectively managed with timely diagnosis, proper treatment, and lifestyle care. Asthma attacks can be fatal if not treated. Millions of people in the U.S. and around the world have asthma. It can start in childhood or develop when you are an adult. It is sometimes called bronchial asthma.

 

What Happens Inside the Lungs – The Pathophysiology of Asthma?

In a healthy person, the airways/tubes that carry air in and out of the lungs are clear and flexible. However, in someone with asthma, these airways are overly sensitive to certain triggers such as dust, pollen, smoke, infections, cold air/weather, strong smells or emotional stress. Asthma is a condition that causes your airways to swell, narrow and fill with mucus.

 

When exposed to these triggers, several things occur inside the lungs:

  1. Inflammation: The inner lining of the airways becomes swollen and inflamed. This narrows the space through which air can flow.
  2. Bronchoconstriction: The muscles surrounding the airways tighten, further narrowing the passage.
  3. Mucus Production: The airways produce excess mucus, making breathing even more difficult.

 

Together, these changes make the airways narrow, sticky, and hyperactive reactive, causing the classic symptoms of asthma — coughing, wheezing, and shortness of breath. During a severe asthma attack, oxygen levels in the blood can drop quickly, requiring urgent medical attention. Understanding these changes helps patients appreciate why long-term inflammation control is vital in asthma management not just relief during attacks.

 

Various environmental and personal triggers can bring asthma attacks. Asthma triggers can bring on an attack right away. Or it might take hours or days for an attack to start after you’re exposure to a trigger. Keeping a diary of symptoms and triggers helps individuals and doctors design better control strategies.

 

Common Symptoms

Major Triggers

·       Wheezing:  A whistling or high-pitched sound when breathing, especially during exercise or exertion.

·       Coughing: A persistent cough that may produce mucus, especially at night or early morning.

·       Chest tightness: A feeling of constriction or pressure in the chest.

·       Shortness of breath: Difficulty breathing, even with mild activity.

·       Allergies: Dust mites, pollen, mold, pet dander

·       Air pollution, smoke: Cigarette smoke vehicle fumes and strong odors

·       Respiratory infections: Common colds and flu can worsen asthma symptoms

·       Weather changes: Cold weather or humid air especially in winter

·       Emotional stress: Intense laughter or crying can sometimes trigger symptoms.

·       Exercise: especially intense physical activity and cold-weather sports

 

What are the types of Asthma?

  • Allergic asthma: when allergies trigger asthma symptoms
  • Cough-variant asthma: when your only asthma symptom is a cough
  • Exercise-induced asthma: when exercise triggers asthma symptoms
  • Occupational asthma: when substances you breathe in at work cause you to develop asthma or trigger asthma attacks
  • Asthma-COPD overlap syndrome (ACOS): when you have both asthma and COPD (chronic obstructive pulmonary disease)

 

Describe Treatment and Management Measures

Asthma management is built on two pillars — long-term control and quick relief.

1.     Long-term Control Medications

o   Inhaled corticosteroids are the most effective medicines for reducing airway inflammation.

o   Long-acting bronchodilators and leukotriene modifiers may also be prescribed to keep symptoms under control.

o   These are taken daily to prevent attacks and maintain normal lung function.

2.     Quick-Relief (Rescue) Medications

o   Short-acting bronchodilators provide immediate relief during an asthma attack by relaxing the airway muscles.

o   However, if these are needed frequently, it signals poor control and the need for adjustment of long-term medications.

3.     Allergen and Trigger Management

o   Keeping living areas dust-free, avoiding tobacco smoke, and using air purifiers can significantly reduce symptoms.

o   For some patients, allergy immunotherapy may help reduce sensitivity to allergens over time.

4.     Regular Monitoring

o   Peak flow meters help measure how well air moves out of the lungs. Monitoring these readings help detect worsening asthma early.

o   Regular follow-ups with a doctor ensure medication plans remain effective and safe.

 

Lifestyle Support and Awareness: Beyond medicine, lifestyle adjustments play a vital role. Regular light exercise (as advised by physicians), maintaining a healthy diet & a healthy weight, managing stress, and taking flu vaccines against respiratory infections annually can all help prevent flare-ups. Asthma is not a barrier to living a full, active life. With the right treatment and awareness, patients can breathe easier and confidently participate in everyday activities — school, sports, work and travel.

 

A Message for the Community: Asthma is not “just a cough” — it is a chronic inflammatory condition that demands attention and care. Public awareness, early diagnosis, and patient education remain the most powerful tools in reducing the global burden of asthma. When we understand the causes behind it, we empower those who live with it to breathe freely again. Early diagnosis and adherence to treatment can prevent serious attacks and hospitalizations.

 

What to do

When to talk to your healthcare provider

·      Keep your environment clean and smoke-free

·      Use prescribed inhalers regularly

·      Get vaccinated for flu and pneumonia

·      Monitor symptoms with a peak flow meter

·      Consult a doctor if symptoms worsen

 

·      Anxiety or panic

·      Bluish, whitish or grayish fingernails, lips or gums

·      Chest pain or pressure

·      Coughing that won’t stop

·      Severe wheezing when you breathe

·      Difficulty talking or swallowing

·      Pale, sweaty face

·      Rapid breathing

 


  



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